MAP2K2 CLIA Kit for Human(Homo sapiens) | EIAab.comMAP2K2 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > MAP2K2(Gene name) > Human

MAP2K2 (Gene name),

Dual specificity mitogen-activated protein kinase kinase 2 (Protein name ), MP2K2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

MAP2K2(MEK2;MKK2;PRKMK2);

Protein name:

Dual specificity mitogen-activated protein kinase kinase 2(MAP kinase kinase 2;MAPKK 2);

Alternative:

MAPK/ERK kinase 2(MEK 2);ERK activator kinase 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MORG1.

Function:

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

400

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

601263

KEGG:

hsa:5605

String:

P36507

STRING:

9606.ENSP00000262948

UniGene:

Hs.465627

MIM:

115150

Pfam:

PF00069

SMR:

P36507

Uniprot:

P36507

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ELISA Kit for Human MAP kinase kinase 2

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E10344d

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96T

ELISA Kit for Human MAP kinase kinase 2

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E10344h

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96T

ELISA Kit for Human MAP kinase kinase 2

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E10344m

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96T

ELISA Kit for Human MAP kinase kinase 2

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E10344r

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96T

ELISA Kit for Human MAP kinase kinase 2

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E10344c

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96T

CLIA Kit for Human MAP kinase kinase 2

Cat.:

U10344d

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96T

CLIA Kit for Human MAP kinase kinase 2

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U10344h

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96T

CLIA Kit for Human MAP kinase kinase 2

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U10344c

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96T

CLIA Kit for Human MAP kinase kinase 2

Cat.:

U10344r

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96T

CLIA Kit for Human MAP kinase kinase 2

Cat.:

U10344m

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96T

Polyclonal Antibody for Human MAP kinase kinase 2

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P10344Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human MAP kinase kinase 2

Cat.:

P10344Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human MAP kinase kinase 2

Cat.:

P10344Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human MAP kinase kinase 2

Protein for Human MAP kinase kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2."
Zheng C.-F. , Guan K.-L.
J. Biol. Chem.268:11435-11439(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Muscle.
tissue: Skin.
3.

Bienvenut W.V. , Zebisch A. , Kolch W.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 40-51; 53-61; 64-100; 102-112; 164-172; 194-205; 265-297; 362-371 AND 389-397;PHOSPHORYLATION AT THR-394;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Colon carcinoma.
4.

"Acetylation of MEK2 and I kappa B kinase (IKK) activation loop residues by YopJ inhibits signaling."
Mittal R. , Peak-Chew S.Y. , McMahon H.T.
Proc. Natl. Acad. Sci. U.S.A.103:18574-18579(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 210-231;INACTIVATION BY YERSINIA YOPJ;PHOSPHORYLATION AT SER-222 AND SER-226;ACETYLATION AT SER-222 AND SER-226;IDENTIFICATION BY MASS SPECTROMETRY
5.

"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor."
Duesbery N.S. , Webb C.P. , Leppla S.H. , Gordon V.M. , Klimpel K.R. , Copeland T.D. , Ahn N.G. , Oskarsson M.K. , Fukasawa K. , Paull K.D. , Vande Woude G.F.
Science280:734-737(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY ANTHRAX LETHAL FACTOR
6.

"Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor."
Vitale G. , Bernardi L. , Napolitani G. , Mock M. , Montecucco C.
Biochem. J.352:739-745(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY ANTHRAX LETHAL FACTOR
7.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
9.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-293 AND SER-295;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND THR-396;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Protein kinase SGK1 enhances MEK/ERK complex formation through the phosphorylation of ERK2: implication for the positive regulatory role of SGK1 on the ERK function during liver regeneration."
Won M. , Park K.A. , Byun H.S. , Kim Y.R. , Choi B.L. , Hong J.H. , Park J. , Seok J.H. , Lee Y.H. , Cho C.H. , Song I.S. , Kim Y.K. , Shen H.M. , Hur G.M.
J. Hepatol.51:67-76(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SGK1
13.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
15.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-295 AND THR-394;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-394 AND THR-396;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome."
Rodriguez-Viciana P. , Tetsu O. , Tidyman W.E. , Estep A.L. , Conger B.A. , Cruz M.S. , McCormick F. , Rauen K.A.
Science311:1287-1290(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CFC4 CYS-57
19.

"Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome."
Schulz A.L. , Albrecht B. , Arici C. , van der Burgt I. , Buske A. , Gillessen-Kaesbach G. , Heller R. , Horn D. , Hubner C.A. , Korenke G.C. , Konig R. , Kress W. , Kruger G. , Meinecke P. , Mucke J. , Plecko B. , Rossier E. , Schinzel A. , more...
Clin. Genet.73:62-70(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CFC4 VAL-57 AND HIS-134
20.

"Molecular and functional analysis of a novel MEK2 mutation in cardio-facio-cutaneous syndrome: transmission through four generations."
Rauen K.A. , Tidyman W.E. , Estep A.L. , Sampath S. , Peltier H.M. , Bale S.J. , Lacassie Y.
Am. J. Med. Genet. A152:807-814(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CFC4 GLN-128;CHARACTERIZATION OF VARIANT CFC4 GLN-128

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